Malaria is an important tropical mosquito-borne infectious disease. In this article, the author briefly reviewed headache profile in patients with malaria focusing on its mechanism. Headache is an important presentation in malaria, either cerebral type or not. The cytokine is believed to be an important factor leading to headache in acute malaria. Some antimalarial drugs can cause headaches. In addition, headache is one of the symptoms of postmalaria neurologic syndrome.