Impact of Growth Hormone Therapy on Quality of Life in Adults with Turner Syndrome
Journal of Clinical Endocrinology and Metabolism
Context: GH and/or oxandrolone are used to promote growth in Turner syndrome (TS). Objective: The aim of this study was to compare quality of life (QoL) in TS women with controls and determine the impact of growth promoting therapy on QoL in TS women. Design: This was a cross-sectional, case-control study. Setting: The study was conducted at an outpatient clinic at Patients: Patients included 111 TS women (age range 18 -59 yr) and 111 randomly selected, agematched women (25-54 yr) from the
... 4 yr) from the World Health Organization Monitoring Trends and Determinants for Cardiovascular Disease project (Gö teborg, Sweden) served as controls. Main Outcome Measures: QoL was estimated by the Psychological General Well-Being scale (anxiety, depressed mood, positive well-being, self-control, general health and vitality) and the Nottingham Health Profile (physical mobility, pain, sleep, energy, social isolation, and emotional reactions). Results : TS women reported more social isolation than controls (P Ͻ 0.001). After age adjustment, significantly less pain (Ͻ0.05) was reported attributable to GH treatment within TS. No significant difference in any other subscales used could be shown. In TS, QoL was negatively affected by higher current age and age at diagnosis and positively affected by better body balance, fine motor function, and higher bone mineral density. Conclusions: Social isolation was more commonly reported in the whole TS cohort than in the population. Except for less pain, no significant impact on QoL attributable to GH treatment could be found, despite the mean ϩ5.1 cm final height. (J Clin Endocrinol Metab 95: 1355-Body weight was measured to the nearest 0.1 kg in the fasting state with the subjects in their underwear and barefoot. Body 1356 Amundson et al.