Original Article To study the correlation of serum vitamin D3 level and degree of control in asthmatic children on inhaled corticosteroids

Nithiyanantham Ramakrishnan, Shobhana Sivathanu, Andrea Josephine, Sowmya Sampath
Childhood asthma is more of a syndrome with complex interplay of gene-environment-lifestyle factors not only for its causation but also for its control with pharmacological therapy. Vitamin D deficiency has been implicated as a risk factor for the causation of asthma and for its poor control in children. Objective: To study the correlation of serum vitamin D3 level and degree of control in asthmatic children on inhaled corticosteroids. Methods: It was an observational study conducted in the
more » ... onducted in the pediatric asthma clinic of a Government Medical College Hospital. The study population consisted of 75 asthmatic children aged 5-15 years. Children with persistent asthma on inhaled corticosteroids were classified into three groups based on global initiative for asthma guidelines. Serum vitamin D levels were measured in all the three groups and an attempt was made to find a correlation between asthma control and vitamin D levels. Results: Among the study group, 33% belonged to controlled group, 35% to uncontrolled group and 33% to partly controlled group. 71% of the asthmatic children were found to be either vitamin D deficient/insufficient. Around 81% of uncontrolled asthmatic children were vitamin D deficient, whereas only 12% of well controlled asthmatics had documented vitamin D deficiency. Among the children in controlled group, the majority (72%) were found to have normal vitamin D status. On comparison of asthma control between the groups, there was a statistically significant difference in vitamin D levels between controlled and uncontrolled group (p<0.001). The majority of children in the uncontrolled group constituted girls (69.2%) and 94% of them were vitamin D deficient. Conclusion: Vitamin D deficiency/insufficiency is widely prevalent in children with persistent asthma and lower levels of vitamin D are associated with poor asthma control. Girls formed a greater percentage of uncontrolled group and majority of them were vitamin D deficient.