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DNA-guided genome editing using structure-guided endonucleases
2016
Genome Biology
The search for novel ways to target and alter the genomes of living organisms accelerated rapidly this decade with the discovery of CRISPR/Cas9. Since the initial discovery, efforts to find alternative methods for altering the genome have expanded. A new study presenting an alternative approach has been demonstrated that utilizes flap endonuclease 1 (FEN-1) fused to the Fok1 endonuclease, which shows potential for DNA-guided genome targeting in vivo.
doi:10.1186/s13059-016-1055-4
pmid:27640875
pmcid:PMC5025577
fatcat:es5jzx4gyrbxljfrjwcnpdm64i