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Free cholesterol in atherosclerotic plaques: where does it come from?
2007
Current Opinion in Lipidology
Purpose of review Free cholesterol in plaques is an emerging contributing factor to lesion instability and, until recently, apoptosis of lipid-laden macrophages was considered the major source of free cholesterol. The validity of this concept is beginning to be challenged since there is recent evidence of erythrocyte membrane-derived cholesterol in plaques. Therefore, intraplaque hemorrhage may not be a passive event, as once considered as studies continue to support the relationship of
doi:10.1097/mol.0b013e3282efa35b
pmid:17885419
fatcat:2lxdqrz27ndfjosugcokx2daaq