Evidence-based Danish Guidelines for the Treatment of Malassezia-related Skin Diseases

M Hald, M Arendrup, E Svejgaard, R Lindskov, E Foged, D Saunte
2015 Acta Dermato-Venereologica  
Internationally approved guidelines for the diagnosis and management of Malassezia-related skin diseases are lacking. Therefore, a panel of experts consisting of dermatologists and a microbiologist under the auspices of the Danish Society of Dermatology undertook a data review and compiled guidelines for the diagnostic procedures and management of pityriasis versicolor, seborrhoeic dermatitis and Malassezia folliculitis. Main recommendations in most cases of pityriasis versicolor and
more » ... olor and seborrhoeic dermatitis include topical treatment which has been shown to be sufficient. As first choice, treatment should be based on topical antifungal medication. A short course of topical corticosteroid or topical calcineurin inhibitors has an anti-inflammatory effect in seborrhoeic dermatitis. Systemic antifungal therapy may be indicated for widespread lesions or lesions refractory to topical treatment. Maintenance therapy is often necessary to prevent relapses. In the treatment of Malassezia folliculitis systemic antifungal treatment is probably more effective than topical treatment but a combination may be favourable. The lipophilic yeast Malassezia is a common commensal of adult human skin particularly in the lipid-rich skin areas, such as the face, scalp, chest and back. The genus Malassezia comprise at least 14 different species: M. furfur, M. sympodialis, M. globosa, M. obtusa, M. restricta, M. slooffiae M. dermatis, M. japonica, M. nana, M. yamatoensis, M. equina, M. caprae, M. cuniculi and M. pachydermatis (1). Malassezia can cause various skin diseases, including pityriasis versicolor (PV), Malassezia folliculitis and seborrhoeic dermatitis (SD), which are all common skin diseases. Allthough European guidelines exist for the diagnosis and treatment of rare invasive yeast infections
doi:10.2340/00015555-1825 pmid:24556907 fatcat:55mueuusq5bhznykbif222wkyi