Possible Therapeutic Potential of Disulfiram for Multiple Myeloma

Denisa Weiser Drozdkova, Katerina Smesny Trtkova
2021 Current Oncology  
Multiple myeloma (MM) is a malignant disease of the plasma cells representing approximately 10% of all hemato-oncological diseases. Detection of the disease is most probable at around 65 years of age, and the average survival of patients is estimated to be 5–10 years, specifically due to frequent relapses and resistance to the therapy used. Thus, the search for new therapeutic approaches is becoming a big challenge. Disulfiram (DSF), a substance primarily known as a medication against
more » ... , has often been mentioned in recent years in relation to cancer treatment for its secondary anti-cancer effects. Recent studies performed on myeloma cell lines confirm high inhibition of the cell growth activity if a complex of disulfiram and copper is used. Its significant potential is now being seen in the cure of haematological malignities.
doi:10.3390/curroncol28030193 pmid:34205025 fatcat:pbdl4z3yjvew7ltypguy47jv7y