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The reasons for the association of the human major histocompatibility complex protein HLA-B27 with spondyloarthropathies are unknown. To uncover the underlying molecular causes, we determined the crystal structures of the disease-associated B*2705 and the nonassociated B*2709 subtypes complexed with the same nonapeptide (GRFAAAIAK). Both differ in only one residue (Asp 116 and His 116 , respectively) in the Fpocket that accommodates the peptide C terminus. Several different effects of the Aspdoi:10.1074/jbc.m206392200 pmid:12244049 fatcat:hw34hi7fd5dznewz3dyicuhubm