The etiology of diseases driven by dysregulated mRNA metabolism can be elucidated by characterizing the responsible RNA-binding proteins (RBPs). Although characterizations of RBPs have been mainly focused on their binding sequences, not much has been investigated about their preferences for RNA structures. We present nearBynding, an R/Bioconductor pipeline that incorporates RBP binding sites and RNA structure information to discern structural binding preferences for an RBP. nearBynding

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... s RNA structure at and proximal to sites of RBP binding transcriptome-wide, analyzes CLIP-seq data without peak-calling, and provides a flexible scaffold to study RBP binding preferences relative to diverse RNA structure data types.