A Substance p Agonist Acts as an Adjuvant to Promote Hapten-Specific Skin Immunity

Hironori Niizeki, Iwao Kurimoto, J. Wayne Streilein
1999 Journal of Investigative Dermatology  
Because substance p (SP) has been reported to be released from cutaneous sensory nerve endings after hapten application, we determined whether SP participates in contact hypersensitivity (CH) induction by using a SP agonist, GR73632 or δ-Aminovaleryl [Pro 9 , N-Me-Leu 10 ]-substance P 7-11 and a SP antagonist, spantide I. When injected intradermally, SP agonist enhanced CH induced by conventional, but not optimal, sensitizing doses of hapten. By contrast, SP antagonist inhibited the induction
more » ... CH by optimal sensitizing doses of hapten. Moreover, SP agonist promoted CH induction and prevented tolerance when hapten was painted on skin exposed to acute, low-dose ultraviolet-B radiation. Intradermally
doi:10.1046/j.1523-1747.1999.00534.x pmid:10201526 fatcat:gnojfbh3cbgkziaq62tnhcgdue