Influence of methyl and isopropyl N-methyl antranilates on carbon tetrachloride-induced changes in rat liver morphology and function

Niko Radulovic, Pavle Randjelovic, Nikola Stojanovic, Ivan Ilic, Ana Miltojevic
2013 Facta universitatis - series Physics Chemistry and Technology  
The aim of the present study was to examine potential protective effects of methyl N-methylanthranilate (M) and isopropyl N-methylanthranilate (I) in a rat model of acute intoxication with carbon tetrachloride (CCl 4 ) by tracking the changes in liver morphology and function. Serum transaminase and bilirubin were significantly elevated in animals treated with CCl 4 alone. A pretreatment with M and I prior to the administration of CCl 4 significantly prevented the increase of serum levels of
more » ... serum levels of liver damage markers. Histopathological evaluation of the livers of the test animals also revealed that M and I reduced the incidence of liver lesions. Our experiments showed that both M and I possess protective effect in CCl 4 -induced liver damage in rats. The results are of interest due to the presence of natural or synthetic M in the human diet. U ovom radu ispitivano je potencijalno protektivno dejstvo metil N-metilantranilata (M) i izopropil N-metilantranilata (I) u modelu akutne intoksikacije pacova sa ugljen-tetrahloridom (CCl 4 ) praćenjem promena u morfologiji i funkciji jetre. Kod životinja tretiranih sa samo CCl 4 značajno su bile povećane vrednosti transaminaza i bilirubina u serumu. Pretretman sa M i I značajno je umanjio porast serumskih markera oštećenja jetre. Patohistološka analiza tkiva jetre pokazala je da M i I smanjuju stepen oštećenja jetre. Ovaj eksperiment je pokazao da i M i I imaju protektivno dejstvo kod oštećenja jetre izazvanog CCl 4 . Ovi rezultati su značajni zbog prisustva prirodnog ili sintetskog M u ljudskoj ishrani.
doi:10.2298/fupct1301067r fatcat:ur6b34mjhzemhlb3w7bumbrn2y