Clinical applications of frequency-domain optical mammography

Sergio Fantini, Oliver Schuetz, Julian Edler, Sylvia Heywang-Koebrunner, Linda Goetz, Maria-Angela Franceschini, Horst Siebold, David A. Benaron, Britton Chance, Marco Ferrari, Matthias Kohl-Bareis
1998 Photon Propagation in Tissues IV  
We present clinical results obtained with a frequency-domain (70 MHz), four-wavelength (690, 750, 788, 856 nm) prototype for optical mammography. The two-dimensional projection images are taken on the slightly compressed breast in craniocaudal and oblique projections, similar to what is done in x-ray mammography. The amplitude and phase images are combined to enhance the contrast and the tumor detectability by reducing the edge effects caused by the breast thickness variations within the
more » ... area. The analysis of the first set of clinical data (63 patients) has yielded encouraging results. The success rate in the detection of breast cancer was 73%, and specificity was 49%. A comparison of the optical mammograms at the four wavelengths in the range 690-856 nm suggests that spectral information may allow for the discrimination of benign and malignant breast lesions, thereby enhancing specificity. Keywords: Frequency-domain spectroscopy, near-infrared, optical mammography, breast cancer. Recent clinical trials of frequency-domain optical mammography performed with a prototype developed by the Carl Zeiss Optics Laboratories 21 have yielded promising results in terms of tumor detectability, 13,22,23 reporting a sensitivity to breast cancer higher than 70%. The clinical data reported in this contribution have been collected with a similar prototype developed at Siemens Medical Technology. 24 The purpose of the analysis of these clinical data is twofold: (1) confirm the previously reported results of sensitivity on an independent clinical data set; (2) investigate the false positive cases to obtain indications about the possible approaches to improve specificity.
doi:10.1117/12.334368 fatcat:unspkniarfa6bdgx3c5vxuqlia