It is well-known that the origin of the life was more likely to have occurred in the ocean. The mechanism of calci cation developed by marine creatures was useful not only for determination of the shape of the body but also for the evolution into creatures such as hermatypic corals which play important roles in the marine environment by building reefs. Eventually, this process became osteogenesis, enabling the di erentiation into various bones including oral teeth, which led to the evolution of

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... vertebrate animals with high exibility and physical mobility. In evolutions of creatures with developing of their bones in response to various environments, it was undi erentiated osteogenic cells which enabled the evolution of bones in various parts of the body. In human evolution, this mechanisms of osteogenesis played an important role and it was maintained in the evolutionary process. Under normal circumstances, calci cation only occurs in bone tissues; however this mechanism sometimes malfunctions. It is called an ectopic calci cation in which calcium is deposited abnormally in soft tissues. Recently, it was shown that A wave of ultraviolet rays (UVA) irradiation induced this phenomenon in cultured cells. Therefore, it is considered that this phenomenon may be also caused in human skin. This review article is considered about a phenomenon of calcium accumulation induced by UVA irradiation in cultured human broblasts through the acquisition of osteogenesis mechanism in evolution from the invertebrate to the vertebrate. At the last, this review article describes about a possibilities for an application of deep seawater as a prevention method in regard to this phenomenon.