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Expression of Activin A and Follistatin Core Proteins by Human Prostate Tumor Cell Lines
Activin and follistatin (FS) messenger RNA and protein are expressed and localized to human prostate tissue from men with high grade cancer and to human prostate tumor cell lines LNCaP, DU145, and PC3. Although activin A induces apoptosis and inhibits cell proliferation in LNCaP cells, PC3 cells are insensitive to the effect of exogenous addition of activin A. The results of this study show that activin A and FS are produced and can be measured by specific enzyme-linked immunosorbent assays indoi:10.1210/en.140.11.5303 pmid:10537161 fatcat:sjpa7v6xw5dhnidsioeck4shve