Circular RNAs in gastrointestinal cancer: Current knowledge, biomarkers and targeted therapy (Review)

Xiaorui Zhao, Yue Wang, Qiongfang Yu, Pei Yu, Qiaoyu Zheng, Xue Yang, Dian Gao
2020 International Journal of Molecular Medicine  
Circular RNAs (circRNAs) are a type of endogenous non‑coding RNAs that are connected at the 3' and 5' ends by exon or intron cyclization, which forms a covalently closed loop. They are stable, well conserved, exhibit specific expression in mammalian cells and can function as microRNA (miRNA or miR) sponges to regulate the target genes of miRNAs, which influences biological processes. Such as tumor proliferation, invasion, metastasis, apoptosis and tumor stage. circRNAs represent promising
more » ... ates for clinical diagnosis and treatment. In the present review, the biogenesis, classification and functions of circRNAs in tumors are briefly summarized and discussed. In addition, the participation of circRNAs in signal transduction pathways regulating gastrointestinal cancer cellular functions is highlighted.
doi:10.3892/ijmm.2020.4731 pmid:33000182 pmcid:PMC7521476 fatcat:r2ffk2omdbe2xdcxbnfwfllwgu