1SCP-02 Scaling of Dorsal-Ventral Patterning by Embryo Size-Dependent Degradation of Chordin(1SCP Challenges to in vivo biophysics,Symposium,The 51th Annual Meeting of the Biophysical Society of Japan)
1SCP-02 胚サイズ依存的な背腹軸パターンのスケーリング機構(1SCP In vivoの生物物理学への挑戦,シンポジウム,日本生物物理学会第51回年会(2013年度))

Hidehiko Inomata, Tatsuo Shibata, Yoshiki Sasai
2013 Seibutsu Butsuri  
Cell-cell interactions in multicellular organisms play crucial roles during normal development and homeostasis. 'Cell competition' is a form of cellcell interactions in which cells with higher fitness survive and proliferate at the expense of neighboring cells with lower fitness. In Drosophila imaginal epithelia, clones of cells mutant for apico-basal polarity genes are eliminated by cell competition. To dissect the mechanism of this nonautonomous regulation of cell competition, we developed a
more » ... non-cell autonomous" genetic screen system. We isolated elimination-defective (eld) mutants that failed to eliminate neighboring polarity-deficient cells. The mechanism by which eld genes regulate the cell-elimination will be discussed.
doi:10.2142/biophys.53.s88_2 fatcat:ma2axtnblbhjxhspaihnyqdite