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Clinical and genetic validity of quantitative bipolarity
2019
Translational Psychiatry
Research has yet to provide a comprehensive understanding of the genetic basis of bipolar disorder (BP). In genetic studies, defining the phenotype by diagnosis may miss risk-allele carriers without BP. The authors aimed to test whether quantitatively detected subclinical symptoms of bipolarity identifies a heritable trait that infers risk for BP. The Quantitative Bipolarity Scale (QBS) was administered to 310 Old Order Amish or Mennonite individuals from multigenerational pedigrees; 110
doi:10.1038/s41398-019-0561-z
pmid:31527585
pmcid:PMC6746871
fatcat:nfl35ftpmrchvne72nx24t75vu