Regulation by Small RNAs in Bacteria: Expanding Frontiers

Gisela Storz, Jörg Vogel, Karen M. Wassarman
2011 Molecular Cell  
Research on the discovery and characterization of small, regulatory RNAs in bacteria has exploded in recent years. These sRNAs act by base pairing with target mRNAs with which they share limited or extended complementarity, or by modulating protein activity, in some cases by mimicking other nucleic acids. Mechanistic insights into how sRNAs bind mRNAs and proteins, how they compete with each other, and how they interface with ribonucleases are active areas of discovery. Current work also has
more » ... un to illuminate how sRNAs modulate expression of distinct regulons and key transcription factors, thus integrating sRNA activity into extensive regulatory networks. In addition, the application of RNA deep sequencing has led to reports of hundreds of additional sRNA candidates in a wide swath of bacterial species. Most importantly, recent studies have served to clarify the abundance of remaining questions about how, when, and why sRNA-mediated regulation is of such importance to bacterial lifestyles.
doi:10.1016/j.molcel.2011.08.022 pmid:21925377 pmcid:PMC3176440 fatcat:egfmxbkt65ekbg35ab6x6efi7q