Although many diseases have an association with depression, cardiac problems tend to affect person's emotional status by depression and physical status by affecting the quality of life. This research is to asses this relation in order to find the association of STEMI patients and cardiac arrest patients in quality of life and depression. Methods: The data have been conducted by questionnaire forms, the research is retrospective, done in a crosssectional method and it is quantitative type of

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... arch. Inclusion criteria include Pateints who presented to hospital with STEMI and patients who came with STEMI and had experienced cardiac arrest. Exclusion criteria include cardiac arrest secondary to non-cardiac etiology and patients early in psychiatric medication prior STEMI event. This study is conducted in Cardiac Catheterlization laboratory at King Abdulaziz Cardiac Center (KACC). Sample size of 190 patients. Results: The research results indicated that there are positive association between depression and patients who had STEMI, our sample size is 190 patients, 171 (90%) were male, whereas 19 (10%) were female. The mean age of 55, mean BMI of 17.69, and mean heart rate of 78 . One of the main point in our result, 87 (45.8%) patients were depressed, 90 (47.9%) were diabetic patients, 80 (45.5%) were hypertensive, (24.3%) have done CABG surgery, 30 (62.5%) have done PCI and 12 (6.5%) experienced cardiac arrest. Data were analyzed by using the statistical software; IBM SPSS Statistics 22.0. For continuous variables, data were reported as mean and standard deviation. Chi-square test were used to compare between depression subgroups. Conclusion: Overall, our findings indicated that there is significant evidence that STEMI patients are susceptible to other disorders like depression, which worsen the patient's condition. Furthermore, quality of life may decreases in post STEMI patients. Other factors may increase that depression. However, clinical practice can help in post STEMI and cardiac arrest conditions.