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Biophysical and Physiological Origins of Blood Oxygenation Level-Dependent fMRI Signals
2012
Journal of Cerebral Blood Flow and Metabolism
After its discovery in 1990, blood oxygenation level-dependent (BOLD) contrast in functional magnetic resonance imaging (fMRI) has been widely used to map brain activation in humans and animals. Since fMRI relies on signal changes induced by neural activity, its signal source can be complex and is also dependent on imaging parameters and techniques. In this review, we identify and describe the origins of BOLD fMRI signals, including the topics of (1) effects of spin density, volume fraction,
doi:10.1038/jcbfm.2012.23
pmid:22395207
pmcid:PMC3390806
fatcat:ysnuzc5tjrbkhn34p2ar22flda