Vitamin A (all-trans-retinol) derivatives are collectively referred to as retinoids. It is FDA approved to treat acne. We aimed to assess the prevalence, knowledge, attitude, and practice of using topical retinoids among all the region's populations. Methods: A cross-sectional study was carried out in all Saudi Arabian regions from October 2021 to November 2021 through a verified electronic-based self-administered questionnaire. Results: The survey questionnaire was completed by a total of

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... people. In Saudi Arabia, the frequency of acne among males and females is approximately 73.2 percent. The subject's knowledge of topical retinoids contraindicates is spread out between 44.6 percent and 77.5 percent. Approximately half of the study participants took topical retinoids without a prescription. Conclusion: In this study, the most commonly reported effect after using topical retinoids was a reduction in acne formation. This indicates that topical retinoids have a very good effect in the treatment of acne. The other preferable outcomes to use retinoids include preventing wrinkles and facial lines, as well as enhancing skin brightness. The majority did not seek a medical prescription for topical retinoids and did not utilize them properly, which lowered their satisfaction with the benefits of topical retinoids.