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NMDA-receptor antagonist and morphine decrease CRPS-pain and cerebral pain representation
A combination therapy of morphine with an NMDA-receptor antagonist might be more effective than morphine without a NMDA-receptor antagonist for the relief of neuropathic pain in patients with complex regional pain syndrome (CRPS). In order to test the efficacy of this combination therapy we performed a double-blind randomized placebo-controlled study on patients suffering from CRPS of the upper extremity. We used functional magnetic resonance imaging during movement of the affected anddoi:10.1016/j.pain.2010.06.022 pmid:20630656 fatcat:4xal3gfivvbz3ftou4exiod5cm