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Selenium-binding protein 1 is associated with the degree of colorectal cancer differentiation and is regulated by histone modification
The aim of the present study was to examine the regulation of selenium binding protein 1 (SELENBP1) expression in colorectal cancer (CRC). Samples of cancer tissue and adjacent normal mucosa were collected from 83 CRC patients, and analyzed for SELENBP1 expression by 2D-DIGE, immunoblotting, RT-PCR and immunostaining. Expression levels of SELENBP1, carcinoembryonic antigen (CEA) and alkaline phosphatase (AKP) were determined in cultures of human colon cancer cell lines (SW480, SW620 and HT29)doi:10.3892/or.2014.3141 pmid:24737289 fatcat:dmerdwt4avdvxmrjnmua4bmasa