Microscopic polyangiitis in a case of silica exposure: a rare presentation

Nitesh Gupta, A J Mahendran, Shibdas Chakrabarti, Sumita Agrawal
2019 Monaldi archives for chest disease  
A 28-year-old male was admitted for breathlessness, haemoptysis, fever and fatigue. The patient had occupational exposure to silica dust. Arterial blood gas test ABG revealed hypoxemic respiratory failure. Chest CT demonstrated ground glass opacities with interlobular septal thickening and small centrilobular nodules with patchy areas of consolidation in bilateral lungs. He was mechanically ventilated for refractory hypoxemia. The treatment with cyclophosphamide and methylprednisolone lead to
more » ... covery and extubation. The final diagnosis was diffuse alveolar haemorrhage due to perinuclear antineutrophil cytoplasmic antibody (ANCA)-associated microscopic polyangiitis (p-ANCA-associated MPA). In a tuberculosis endemic country, for patients presenting with diffuse alveolar haemorrhage (DAH), with history of silica exposure, differential diagnosis of ANCA associated vasculitis must be considered.
doi:10.4081/monaldi.2019.1087 pmid:31505920 fatcat:ubuhjo5dmbhr7dbyfqhjet4bca