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Splenic B Cells Act as Antigen Presenting Cells for the Induction of Anterior Chamber-Associated Immune Deviation
Investigative Ophthalmology and Visual Science
PURPOSE. To characterize the role of B cells in the induction of anterior chamber-associated immune deviation (ACAID). METHODS. An in vitro model of the ACAID spleen was used to recapitulate the events that occur when antigen is introduced into the anterior chamber of the eye and culminates in the appearance of antigen-specific, CD8 ϩ suppressor cells. RESULTS. In vitro-generated suppressor cells mimicked those produced by anterior chamber injection of antigen, as shown by their antigendoi:10.1167/iovs.03-0768 pmid:14638723 fatcat:laod4ukbozfovdj63q5vzwijm4