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Cervical Pathology Following HPV Vaccination in Greece: A 10-year HeCPA Observational Cohort Study

EVANGELOS PARASKEVAIDIS, ANTONIOS ATHANASIOU, MARIA PARASKEVAIDI, EVRIPIDIS BILIRAKIS, GEORGIOS GALAZIOS, EMMANUEL KONTOMANOLIS, KONSTANTINOS DINAS, ARISTOTELIS LOUFOPOULOS, MARIA NASIOUTZIKI, IOANNIS KALOGIANNIDIS, APOSTOLOS ATHANASIADIS, ALEXIOS PAPANIKOLAOU (+14 others)
2020 In Vivo  

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https://web.archive.org/web/20201104184751/http://iv.iiarjournals.org/content/34/3/1445.full.pdf

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In Greece the population-level impact of HPV vaccination is unknown due to lack of official registries. This study presents in a pragmatic frame the comparison of cervical pathology data between HPV-vaccinated and unvaccinated women referred for colposcopy. This is an observational prospective cohort study performed in 7 academic Obstetrics and Gynaecology Departments across Greece between 2009-2019. Cases were women that had completed HPV vaccination before coitarche and were referred for
more » ... scopy due to abnormal cytology. For each vaccinated woman an unvaccinated matched control was selected. A total of 849 women who had been vaccinated before coitarche and 849 unvaccinated controls were recruited. The combination of cytological, colposcopic and molecular findings necessitated treatment in only a single case among vaccinated (0.1%) and in 8.4% among unvaccinated. HPV vaccination at a proper age can markedly reduce development of severe cervical precancers and consequently the need for treatment, as well as their long-term related obstetrical morbidity.
doi:10.21873/invivo.11927 pmid:32354944 pmcid:PMC7279786 fatcat:jmowavpzlbazno5u4n2hvcbnki
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EVANGELOS PARASKEVAIDIS, ANTONIOS ATHANASIOU, MARIA PARASKEVAIDI, EVRIPIDIS BILIRAKIS, GEORGIOS GALAZIOS, EMMANUEL KONTOMANOLIS, KONSTANTINOS DINAS, ARISTOTELIS LOUFOPOULOS, MARIA NASIOUTZIKI, IOANNIS KALOGIANNIDIS, APOSTOLOS ATHANASIADIS, ALEXIOS PAPANIKOLAOU, ANASTASIA VATOPOULOU, GREGORIOS GRIMBIZIS, DIMITRIOS TSOLAKIDIS, ALEXANDROS DAPONTE, GEORGE VALASOULIS, STELLA GRITZELI, GEORGIOS MICHAIL, GEORGIOS ADONAKIS, MINAS PASCHOPOULOS, ORESTIS TSONIS, MARIA-EUGENIA ANAFORIDOU, ANNA BATISTATOU, MARIA KYRGIOU, the HeCPA (Hellenic Cervical Pathology Academic) Group. "Cervical Pathology Following HPV Vaccination in Greece: A 10-year HeCPA Observational Cohort Study." In Vivo 34.3 (2020) 1445-1449