Cervical Pathology Following HPV Vaccination in Greece: A 10-year HeCPA Observational Cohort Study

EVANGELOS PARASKEVAIDIS, ANTONIOS ATHANASIOU, MARIA PARASKEVAIDI, EVRIPIDIS BILIRAKIS, GEORGIOS GALAZIOS, EMMANUEL KONTOMANOLIS, KONSTANTINOS DINAS, ARISTOTELIS LOUFOPOULOS, MARIA NASIOUTZIKI, IOANNIS KALOGIANNIDIS, APOSTOLOS ATHANASIADIS, ALEXIOS PAPANIKOLAOU (+14 others)
2020 In Vivo  
In Greece the population-level impact of HPV vaccination is unknown due to lack of official registries. This study presents in a pragmatic frame the comparison of cervical pathology data between HPV-vaccinated and unvaccinated women referred for colposcopy. This is an observational prospective cohort study performed in 7 academic Obstetrics and Gynaecology Departments across Greece between 2009-2019. Cases were women that had completed HPV vaccination before coitarche and were referred for
more » ... scopy due to abnormal cytology. For each vaccinated woman an unvaccinated matched control was selected. A total of 849 women who had been vaccinated before coitarche and 849 unvaccinated controls were recruited. The combination of cytological, colposcopic and molecular findings necessitated treatment in only a single case among vaccinated (0.1%) and in 8.4% among unvaccinated. HPV vaccination at a proper age can markedly reduce development of severe cervical precancers and consequently the need for treatment, as well as their long-term related obstetrical morbidity.
doi:10.21873/invivo.11927 pmid:32354944 pmcid:PMC7279786 fatcat:jmowavpzlbazno5u4n2hvcbnki