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During recent years, experimental data, case reports, and epidemiological studies have suggested an important role for estradiol in bone metabolism in men. In a cohort of 596 men, aged 51-85 yr, we measured bone mineral density (BMD) of the lumbar spine, hip, total body, and forearm; serum levels of sex steroid hormones [total and free testosterone, total estradiol (17␤E 2 ), bioavailable estradiol (bio-17␤E 2 ), androstenedione, and sex hormone-binding globulin]; and markers of bone turnoverdoi:10.1210/jc.86.1.192 pmid:11232000 fatcat:cgi7ejxoxnhhdlcpztb6ip4gze