Formulation of insoluble drugs. Study of pharmaceutical suspensions by response surface methodology

F. Nielloud, G. Marti-Mestres, R. Fortuné, J. P. Mestres, H. Maillols
1998 Analusis  
The preformulation of insoluble drugs, sulfadiazine and aluminium hydroxyde, were studied in order to achieve a suspension with desirable requirements. The objective of the formulator is to avoid the irreversible aggregation called "caking", and to obtain a suspension with an airy, large volume sediment easily redispersible and with suitable rheological properties. An experimental design useful to determine optimal properties is a Central Composite Design. The surfactant, thickener and
more » ... ckener and electrolyte at different proportions are the 3 factors studied. This strategy allows to point on the main significant effect and to determine the concentrations of each product leading to optimal properties of the suspensions.
doi:10.1051/analusis:1998173 fatcat:ifzdcu72rbcezlqzcpqg5xlxqe