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Reprogramming somatic cells without fusion or ethical confusion
Evaluation of: Takahashi K and Yamanaka S: Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126, 663-676 (2006) . Somatic cell nuclear transfer experiments in the past 10 years demonstrate that mammalian cells can be reprogrammed, since the nucleus of a differentiated somatic cell, when injected into an enucleated oocyte, can, upon transfer to a surrogate mother, give rise to an entire organism. Cell fusion of differentiateddoi:10.2217/174607184.108.40.2067 fatcat:l4xoxfzn4begravcotbv6m5kn4