Large Duodenal Somatostatinoma in the Third Portion Associated with Severe Glucose Intolerance

Ryosuke KIMURA, Yoshinari HAYASHI, Toyo TAKEUCHI, Manabu SHIMIZU, Maki HIRATSUKA, Michihiro YOSHIDA, Eiji HAMAJIMA, Masaru IWATA, Masami IMOTO, Hideo HATTORI
2004 Internal medicine (Tokyo. 1992)  
A 51-year-old man was admitted with hyperglycemia and a duodenal tumor. Although his glycemic control was poor, basal C-peptide levels were not suppressed. Further examination revealed a mass measuring 7.8 cm in diameter in the third portion of the duodenum. Duodenectomy revealed a slow-growing sessile tumor located near Treitz's ligament. The immunohistochemical profile of sections of the specimen revealed the presence of somatostatin. The patient's serum somatostatin was elevated to 300 pg/ml
more » ... preoperatively, but was reduced to 10 pg/ml postoperatively. Glycemic control also normalized after the operation. (Internal Medicine 43: 704-707, 2004)
doi:10.2169/internalmedicine.43.704 pmid:15468970 fatcat:fnro5r3o6fh5feraxv76r7r2pi