Young children in institutional care have often been abandoned at birth or soon after because of illegitimate pregnanciesor parental instability. Orphaned, abandoned, and maltreated children pose problems for societies throughout the world. Although the actual number of children in residential institutions is impossible to gauge accurately, estimates have ranged from 2,000,000 to more than 8,000,000 (Browne, 2009; Save the Children, 2009). Most institutions are staffed with caregivers who work

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... otating shifts in rather bleak material conditions.1 The children those most at risk for malnutrition and hunger-related diseases, in particular orphaned or abandoned children living in care centers, many of whom have significant special needs 2. The aim of the study: the study aimed to evaluate the effect of health educational program on the knowledge of care givers regarding infants care in Maygoma Orphanage center. This a center for abandoned children in Khartoum. Material and methods: An Intervention study, conducted in Mygoma orphanage center in Khartoum state from (2016-2017). The total coverage method used to lay down the sample which reaches (50) caregivers. Data was collected by using a questionnaire (to measure the knowledge) and was analyzed by using Statistical Packages for Social Sciences (SPSS version 20). Results: The study showed, significant differences (P < 0.05) found in knowledge of care givers between the pre and post health education program About (58%) of caregivers displayed correct answers regarding the bottle preparation before attending the program, while after the program(82%) of them displayed it correctly. Regarding the time for giving feeding formula to infants, (46%) of care givers gave correct answers before attending the program, in contrast, after the program (94%) of them gave correct answers. (88%)of the care givers answered correctly about how to start bottle feeding before attending the program, while(98%) of them answered correctly after attending the program. Regarding the time for introducing food to infants with Formula, (82 %) of the care givers gave correct answers before attending the program, while all of them (100%) mentioned correctly after the program. Moreover, studying knowledge of caregivers regarding the reasons of infant crying showed (76 %) of them answered correctly before program, while after program (98%) of them mentioned correctly. Conclusion: The study concluded that health educational program had a significant impact related to the improvement of the caregiver's knowledge post application of the program. Recommendation: The study recommended, increase the number of care givers to meet the number of infants, increase the resources.