Issue:1 Citation: Elanchezhiyan Manickan et al. Ijppr

K Vasanthi, M Dhanalakshmi, V Pugalendhi, Elanchezhiyan Manickan
2017 unpublished
HSV infections are ubiquitous and cause significant morbidity worldwide. After a productive primary HSV infection, the virus gets cleared off spontaneously in the majority of the individuals. However, in a proportion of patients, the virus establishes a chronic state known as latent infections in the neurons. In general HSV-1 causes lesions above the waist in contrast HSV-2 below waist although vice versa infections are not uncommon. During latency, the HSV infects the dorsal root ganglion but
more » ... root ganglion but it remains almost silent in terms of replication. Upon a poorly defined trigger or insult, HSV gets reactivated i.e the virus replicate enormously (prodrome phase) and migrate towards the same neuro dermatome through which it entered and cause agonizing painful necrotizing lesions of genitals or mouth. It has been a myth about what is such trigger or insult that provokes recrudescence. It has been postulated that conditions such as stress, Catamenia (menstrual cycle), fever, exposure to sunlight, radiation and trauma either alone or in the combination of multiple factors are believed to be the cause of recurrence. In this paper, we report a novel mechanism that a decrease of normal Th-1 cytokine milieu may trigger the HSV reactivation and recurrent infection.