Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome is a mitochondrial cytopathy that affects many of the body's systems, particularly the nervous and musculoskeletal systems. In most cases, the signs and symptoms of this disorder appear in childhood generally between ages 3-15. Early symptoms may include muscle weakness and pain, recurrent headaches, loss of appetite, vomiting, and seizures. Here, we present a unique case of late onset of symptoms and the resulting disease course following admission.