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AbstractNormal mammalian secondary palate development undergoes a series of processes, including palatal shelf (PS) growth, elevation, adhesion and fusion, and palatal bone formation. It has been estimated that more than 90% of isolated cleft palate is caused by defects associated with the elevation process. However, because of the rapidly completed elevation process, the entire process of elevation will never be easy to clarify. In this article, we present a novel method for three-dimensionaldoi:10.1038/s41368-021-00122-8 pmid:34039957 fatcat:ogaksufhanb25ehpu7zavhst2u