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... torate for Information Operations and Reports (0704-0188), 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. Animal models: A cross between NBL-Tag mice and B-lymphocyte knockout mice were created and described.. CONCLUSION NB-Tag is a robust mouse model of metastatic NBL-NA tumors recapitulating human disease. Our preliminary results reveal anti-tumor effect of treatment with anti-mouse CD20 and lesser effect of isotype control. However the transgenic B-lymphocyte experiments do not directly implicate B-cells in the neuroblastoma pathogenecity in this model. The observations that antibody treatment may delay tumor regrowth will be further examined using in vitro co-culture assays. We are continuing our work on Task 3 using REFERENCES None APPENDICES PDF version of the abstract presented at the CHLA Poster Session.