Intercellular signaling network underlies biological time across multiple temporal scales [article]

Joshua Millstein, Keith C Summa, Xia Yang, Jun Zhu, Huaiyu Mi, Martha H Vitaterna, Fred W Turek, Bing Zhang
2018 bioRxiv   pre-print
Motivation: Cellular, physiological and molecular processes must be organized and regulated across multiple time domains throughout the lifespan of an organism. The technological revolution in molecular biology has led to the identification of numerous genes implicated in the regulation of diverse temporal biological processes. However, it is natural to question whether there is an underlying regulatory network governing multiple timescales simultaneously. Results: Using queries of relevant
more » ... bases and literature searches, a single dense multiscale temporal regulatory network was identified involving core sets of genes that regulate circadian, cell cycle, and aging processes. The network was highly enriched for genes involved in signal transduction (P = 1.82e-82), with p53 and its regulators such as p300 and CREB binding protein forming key hubs, but also for genes involved in metabolism (P = 6.07e-127) and cellular response to stress (P = 1.56e-93). These results suggest an intertwined molecular signaling network that affects biological time across multiple temporal scales in response to environmental stimuli and available resources.
doi:10.1101/315788 fatcat:n4msjgdtrzc33b2onksf4rvgdi