Electrophysiological effects of high cocaine concentrations on intact canine heart. Evidence for modulation by both heart rate and autonomic nervous system

C W Clarkson, C Chang, A Stolfi, W J George, S Yamasaki, A S Pickoff
1993 Circulation  
Background. Previous clinical reports have suggested that cocaine intoxication may produce severe ventricular arrhythmias due to a direct effect on the heart. However, the effects of high plasma levels of cocaine on the electrophysiology of the heart have not been well characterized and remain poorly understood. Methods and Results. The purpose of this study was to characterize the electrophysiological effects of high doses of cocaine on the in situ dog heart. In dogs anesthetized with morphine
more » ... tized with morphine and a-chloralose, cocaine
doi:10.1161/01.cir.87.3.950 pmid:8443914 fatcat:ck2xja25vjbbfoblb64oijtxmi