Influence of feeding artificial-formula milks containing docosahexaenoic and arachidonic acids on the postnatal long-chain polyunsaturated fatty acid status of healthy preterm infants

Magritha M. H. P. Foreman-Van Drongelen, Adriana C. Van Houwelingen, Arnold D. M. Kester, Carlos E. Blanco, Tom H. M. Hasaart, Gerard Hornstra
1996 British Journal of Nutrition  
In view of the importance of long-chain polyunsaturated fatty acids (LCP) for growth and development of fetal and infant neural tissue, the influence of the dietary n-3 and n-6 LCP intake on the LCP status of forty-three preterm infants (birth weight < 1800 g) was studied. Thirty-one formula-fed infants were randomly assigned to receive a conventional formula lacking LCP (n 16), or an 22:6n-3-and 20:&-6enriched formula (n 15); twelve infants received their own mother's breast milk. Fatty acid
more » ... mpositions of plasma and erythrocyte (RBC) phospholipids (PL) were determined in umbilical venous blood, in weekly postnatal samples until day 35 of life and, for the formula-fed infants, at 3 months of corrected age. Both in plasma (P < 0.001) and RBC (P < 0.01) PLY the changes with time until day 35 for 22: 611-3 and 20:&-6 in the two groups of formula-fed infants were sigdicantly different, with higher values, comparable with those of hnman-milk-fed infants, in the LCP-enriched-formula group. At 3 months of corrected age, differences between the two formula-fed groups were even more pronounced. In conclusion, adding 22: 6n-3 and 20 : 4n-6 to artificial formulas in balanced ratios and in amounts similar to those found in preterm human milk raises both the 22:6n-3 and the 20:4n-6 status of formulafed preterm infants to values found for human-milk-fed preterm infants. Additional studies are necessary to evaluate the potentially favourable effects of this combined addition on the neurodevelopmental outcome of preterm infants.
doi:10.1079/bjn19960073 pmid:8958000 fatcat:gxhqrviycvfl3g7cv3smtorbku