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Oxidant-mediated Akt Activation in Human RPE Cells
Investigative Ophthalmology and Visual Science
PURPOSE. To determine whether a model oxidant, hydrogen peroxide (H 2 O 2 ), influences Akt activation and, if so, whether Akt activation promotes retinal pigment epithelial (RPE) cell survival. METHODS. Cultured human RPE cells were pretreated with medium alone, with LY294002 (LY), an inhibitor of phosphatidylinositol-3 kinase (PI3K) and its downstream effector Akt, or with Akt/protein kinase B signaling inhibitor (API)-2, a specific Akt inhibitor, and then were stimulated with H 2 O 2 atdoi:10.1167/iovs.06-0140 pmid:17003457 fatcat:nuvrxwjea5a6tm45gyif3rqrry