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Activity-dependent modulation of synapses is critical for brain development and for many cognitive functions in the mature brain. Amongst the neurotrophins, BDNF has for a unique role in long-term potentiation, a form of synaptic plasticity associated with memory formation, and the consolidation of long-term memory [1,2]. Over the past decade it has been established that neuronal activity regulates bdnf transcription, transport of BDNF mRNA and protein into neuronal processes anddoi:10.1016/j.cub.2005.03.023 pmid:15823529 fatcat:3jeoush33jchvc44u7kvam3r6q