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Transcutaneous carbon dioxide attenuates impaired oxidative capacity in skeletal muscle in hyperglycemia model
General Physiology and Biophysics
Hyperglycemia impairs oxidative capacity in skeletal muscle. Muscle oxidative capacity is regulated by peroxisome proliferator-activated receptor-γ co-activator-1α (PGC-1α). Transcutaneous carbon dioxide (CO 2 ) enhances PGC-1α expression in skeletal muscle. Therefore, the aim of this study was to clarify the effects of CO 2 therapy on muscle oxidative capacity impaired by streptozotocin (STZ)induced hyperglycemia. Eight-week-old male Wistar rats were randomly divided into 4 groups: control, COdoi:10.4149/gpb_2018048 fatcat:htcsjo4swfcd5hxhgcmdnrh7wm