Aegle marmelos belonging to the family Rutaceae is an aromatic slow-growing, medium sized tree with strong straight 1-3 cm long axillary spines. The leaves, borne singly or in 2's or 3's, are composed of 3 to 5 oval, pointed, shallowly toothed leaflets, 4-10 cm long, 2-5 cm wide, the terminal one with a long petiole. This plant is more preferred for its medicinal properties than its edible quality and occupies a distinct position in Indian traditional medicine. Many medicinal properties are

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... med to be possessed by ABSTRACT The Aegle marmelos whole leaf powder (2000mg) and alcohol extract (400mg) chronic oral treatment for 90 days in male Wistar rats caused elevation of serum transaminases and alkaline phosphatases. This was maximum after 60 days of treatment this effect does not substantiate for a toxic impact on liver, as the levels have been found to come towards normalcy after 90 days of treatment and fluctuations in the serum total proteins were also noticed, but they were found to be within normal range. The blood urea and hematological parameters during different duration of treatment showed absence of fluctuations, which indicates no deleterious impact on vital tissues like liver, kidney and bone marrow; the post mortem observation and histopathology studies confirms this and thus it can be suggested that the fluctuations are due to initial stress and cannot be considered as reflection of any permanent toxic injury. These treatments showed a decrease in serum total cholesterol, triglycerides, VLDL, LDL with an increase in HDL. The β-sitosterol and Rutin are reported to posses' hypocholesterolemic effect and the rutin was identified in the alcohol extract. The acute toxicity study of the leaf powder and extracts were non-toxic up to a dose of 2000 mg/ kg b. wt.