Microbial evaluation and spectral assignment of newly synthesized furyl based cyanoiminopyrimidines (3a-3g) have been reported. The method involved: the reaction of 2-Acetyl-5-methylfuran with substituted benzaldehyde using basic alcoholic medium affords styryl-2-furylketones, a substituted α,β-unsaturated ketones(2a-2g).Treatment ofstyryl-2-furylketones with Dicyandiamide in ethanol using sodium hydroxide leads to 2-Cyanoimino-4substituted phenyl-6-(5-methyl-2-furyl)-3,4-dihydropyrimidines.

more »

... synthesized targets were analyzed their spectral data viz. NMR, IR and Mass and assigned their structures. Screened bacterial and fungal activities of synthesized compounds especially the phenyl ring with chloro, methyl and methoxy substitution manifested the good antimicrobial potential.