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We have developed a nanosized agent for targeted antimicrobial photodynamic therapy (aPDT), comprised of GaPpIX (a hemin analog with potent photosensitizer activity) encapsulated in haemoglobin (GaHb), mounted on 10-nm Ag nanoparticles (AgNPs). The average GaHb–AgNP contains 28 GaPpIX units stabilized by Hb αβ-dimer units. Eradication (>6-log reduction) of <i>S. aureus</i> and MRSA can be achieved by a 10-second exposure to 405-nm irradiation from a light-emitting diode (LED) array (140doi:10.26434/chemrxiv.13014008 fatcat:gfzatvqiwjabjmofuemmpdcbry