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Rapid Clearance of Sialylated Glycoproteins by the Asialoglycoprotein Receptor
Journal of Biological Chemistry
The asialoglycoprotein-receptor (ASGP-R) located on liver parenchymal cells was originally identified and characterized on the basis of its ability to bind glycoproteins bearing terminal galactose (Gal) or N-acetylgalactosamine (GalNAc); however, endogenous ligands for the ASGP-R have not to date been definitively identified. We have determined that the rat ASGP-R specifically binds oligosaccharides terminating with the sequence Sia␣2,6GalNAc␤1,4GlcNAc␤1,2Man. Bovine serum albumin chemicallydoi:10.1074/jbc.m210612200 pmid:12464602 fatcat:qunlwwqbgrewxjc2xkibuzrzve