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Upregulation of thrombospondin-1 expression by leptin in vascular smooth muscle cells via JAK2- and MAPK-dependent pathways
American Journal of Physiology - Cell Physiology
Chavez RJ, Haney RM, Cuadra RH, Ganguly R, Adapala RK, Thodeti CK, Raman P. Upregulation of thrombospondin-1 expression by leptin in vascular smooth muscle cells via JAK2-and MAPKdependent pathways. Hyperleptinemia, characteristic of diabetes and a hallmark feature of human obesity, contributes to the increased risk of atherosclerotic complications. However, molecular mechanisms mediating leptininduced atherogenesis and gene expression in vascular cells remain incompletely understood.doi:10.1152/ajpcell.00008.2012 pmid:22592401 fatcat:zaspdkbqnzflhney4ofb67gyzm