Euphorbia lathyris L. has received worldwide attention as a renewable source of industrial raw materials (hydrocarbons and oleic acid) and mass cultivation has been attempted in western Europe and the United States 1 . Owning to therapeutic effect of the plant on the clinic including wart, scabies, hydropsy, boils etc. 2 , the seed of Euphorbia lathyris L. has been received a large amount of attentions 3-5 . Present investigation on the seed of Euphorbia lathyris L. led to a new macrocyclic

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... rpene, designated as Euphorbia lathyris A (1), together with two additional known macrocyclic diterpene, designated as Euphorbia Factor L1 (2) 5,6 and Euphorbia Factor L2 (3) 5,6 . These known compounds were identified by comparing of the respective spectroscopic data with those reported in the literature. We described herein the separation and structure elucidation of the new macrocyclic diterpene. Euphorbia lathyris L. was collected in Chengdu Chinese herbal medicine market, Sichuan province of China in April 2007 and authenticated by Plant Systematics and Molecular Evolution lab of Sichuan University. A voucher specimen was deposited at Leshan Normal University. Optical rotations were measured using a Perkin-Elmer model 241 polarimeter. 1 D and 2 D NMR spectra were measured by a Bruker DRX-400 instrument with TMS as internal standard. Mass spectra were obtained by a VG Auto Spec-3000 spectrometer or on a Finnigan MAT 90 instrument. Column chromatography was performed on silica gel Qingdao Marine Chemical Inc.). Extraction and isolation: Dry seed of Euphorbia lathyris L.