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Dna2 is a nuclease and helicase that functions redundantly with other proteins in Okazaki fragment processing, double strand break (DSB) resection and checkpoint kinase activation. Dna2 is an essential enzyme, required for yeast and mammalian cell viability. Here we report that numerous mutations affecting the DNA damage checkpoint suppress dna2Δ lethality in Saccharomyces cerevisiae . dna2Δ cells are also suppressed by deletion of helicases, PIF1 and MPH1 , and by deletion of POL32 , a subunitdoi:10.1101/263228 fatcat:527cn4zzdvcwfnikwqkjw4hqvy