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Endothelial cell apoptosis induced by bacteria-activated platelets requires caspase-8 and -9 and generation of reactive oxygen species
2008
Thrombosis and Haemostasis
Acommon feature of severe sepsis is vascular inflammationand damage to theendothelium.Because platelets can be directlyactivatedbybacteria and endotoxin, these cells mayplayanimportantrole in determining theoutcomeofsepsis. Forexample,inhibiting plateleti nteractions witht he endothelium has been shownt oa ttenuate endothelialc elld amage and improve survival during sepsis.Althoughnot entirelyunderstood, theinteractions between bacteria-activated platelets and the endothelium mayp layak ey role
doi:10.1160/th07-07-0474
pmid:18278187
fatcat:eltgpv3yxjgtzegz4pfiw4ng5u