Ag Nanoparticles-enhanced Fluorescence of Terbium-Deferasirox Complexes for the Highly Sensitive Determination of Deferasirox

Jafar ABOLHASANI, Roza NADERALI, Javad HASSANZADEH
2016 Analytical Sciences  
We describe the effect of different sized gold and silver nanoparticles on the terbium sensitized fluorescence of deferasirox. It is indicated that silver nanostructures, especially 18 nm Ag nanoparticles (AgNPs), have a remarkable amplifying effect compared to Au nanoparticles. Based on this observation, a highly sensitive and selective method was developed for the determination of deferasirox. Effects of various parameters like AgNPs and Tb 3+ concentration and pH of media were investigated.
more » ... were investigated. Under the optimal conditions, a calibration curve was plotted as the fluorescence intensities versus the concentration of deferasirox in the range of 0.1 to 200 nmol L -1 , and detection limit of 0.03 nmol L -1 was obtained. The method has good linearity, recovery, reproducibility and sensitivity, and was satisfactorily applied for the determination of deferasirox in urine and pharmaceutical samples.
doi:10.2116/analsci.32.381 pmid:27063708 fatcat:pknxbjwcxndx3eqe4ntxpvtqgm